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Stem cells: All about stemness and regeneration
2010.03.21 08:56 Kiehinen Stem cells: All about stemness and regeneration
Welcome to stemcells! The purpose of this subreddit is to highlight exciting research, prospects, experiences, and discussion, as well as to point out the pitfalls and unknowns regarding stem cell therapy.
2015.07.29 22:17 DankVoid Athersys
News and discussion for the company Athersys Inc.
2009.06.02 12:17 bimomib Live better longer.
Reasons to hope to see the age of 100 and beyond: Biomedical rejuvenation through damage repair, manipulation of metabolism, beyond the mere results of exercise, caloric restriction, and fasting. Stem cell therapies, anti-cancer viruses, gene therapy, senolytics, and whatever is coming next... /longevity is the place to find all information about new longevity, healthspan, happyspan, and rejuvenation research related news.
2023.03.30 19:57 BarbFunes FM Patient Education Material from UpToDate
I have access to some patient education resources about Fibromyalgia that are from a top medical resource (UpToDate). I wanted to share the content here because I think they answer a lot of basic questions I find people asking here. They also solidify that FM is not "in your head" but that there is a ton of evidence that it is a neurologically based condition.
What is fibromyalgia?
Fibromyalgia is a condition that causes people to feel pain in the muscles and soft tissues all over their body. People with fibromyalgia also have many places on their body that hurt a lot when they are touched. No one knows what causes fibromyalgia.
Fibromyalgia is one of a group of chronic pain disorders that affect connective tissues, including the muscles, ligaments (the tough bands of tissue that bind together the ends of bones), and tendons (which attach muscles to bones). It is a chronic condition that causes widespread muscle pain (known as "myalgia") and extreme tenderness in many areas of the body. Many patients also experience fatigue, sleep disturbances, headaches, and mood disturbances such as depression and anxiety. Despite ongoing research, the cause, diagnosis, and optimal treatment of fibromyalgia are not clear.
In the United States, fibromyalgia affects about 2 percent of people by age 20, which increases to approximately 8 percent of people by age 70; it is the most common cause of generalized musculoskeletal pain in women between 20 and 55 years. It is more common in women than men.
What causes fibromyalgia?
The cause of fibromyalgia is unknown. Various physical or emotional factors (such as infection, injury, or stress) may play a role in triggering symptoms, although many patients report a lifelong history of chronic pain.
In people with fibromyalgia, the muscles and tendons are excessively irritated by various painful stimuli. This is thought to be due to a heightened perception of pain, a phenomenon called "central sensitization." Other conditions may also develop as a result of central sensitization, including irritable bowel syndrome (IBS); chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); chronic headaches; chronic pelvic and bladder pain; and chronic jaw and facial pain.
There is no generally agreed-upon explanation for how or why central sensitization develops in some people. The most plausible theory suggests that there is a genetic component, meaning that some people are predisposed to having a heightened sense of pain. People with a parent or sibling with fibromyalgia have a higher chance of developing it themselves. In some cases, various stressors, including infection (eg, Lyme disease or viral illness), diseases that involve joint inflammation (eg, rheumatoid arthritis or systemic lupus erythematosus), physical or emotional trauma, or sleep disturbances appear to trigger the development of fibromyalgia.
Brain imaging studies in people with fibromyalgia and related chronic pain disorders have shown changes in brain function and connections between different parts of the brain. As research continues, the factors that lead to chronic pain in fibromyalgia will be better understood, hopefully allowing for the development of better treatments.
Can fibromyalgia be cured?
In some people, fibromyalgia seems to get better. But in most people, it cannot be cured. Even so, people can learn to deal with the condition and lead fairly normal lives. Fibromyalgia does not get worse over time, and it is not life-threatening.
Does fibromyalgia cause symptoms besides muscle pain?
The primary symptom of fibromyalgia is widespread (or "diffuse"), chronic, and persistent pain. Although the pain is felt in muscles and soft tissues, there are no visible abnormalities in these areas. The pain may be described as a deep muscular aching, soreness, stiffness, burning, or throbbing. Patients may also feel numbness, tingling, or unusual "crawling" sensations in the arms and legs. Although some degree of muscle pain is always present, it varies in intensity and is aggravated by certain conditions, such as anxiety or stress, poor sleep, exertion, or exposure to cold or damp conditions. People often describe their muscle symptoms as feeling like they always have the flu.
The pain may be confined to specific areas, often the neck or shoulders, early in the course of the disease. Multiple regions are eventually involved, with most patients experiencing pain in the neck, middle and lower back, arms and legs, and chest wall. Areas called "tender points" can feel painful with even mild to moderate pressure. Many patients with fibromyalgia feel that their joints are swollen, although there is no visible inflammation of the joints (as would be found in forms of arthritis).
Persistent fatigue occurs in more than 90 percent of people with fibromyalgia. Most people complain of unusually light, unrefreshing, or nonrestorative sleep. Difficulties falling asleep, awakening repeatedly during the night, and feeling exhausted upon awakening are also common problems.
People with fibromyalgia may also have sleep apnea (when the person stops breathing for a few moments while sleeping) or restless legs syndrome (when there is an uncontrollable urge to move the legs). Like some painful conditions, these sleep problems might also be triggers of fibromyalgia. If you have one or both of these problems, your doctor will likely recommend a formal sleep evaluation to confirm the diagnosis
Many people with fibromyalgia also have depression and/or anxiety at the time of diagnosis, or develop one or both later in life. However, this is true of most chronic pain conditions, and fibromyalgia is not simply a physical manifestation of depression.
They can also have:
Is there a test for fibromyalgia?
No, there is no test. To diagnose it, doctors and nurses review your symptoms. If you have symptoms of fibromyalgia, your doctor should obtain a medical history and do a physical exam to rule out arthritis, other connective tissue problems, neurologic conditions, and other disorders that may be causing your symptoms.
Routine laboratory tests may be recommended to help exclude certain conditions, such as inflammatory arthritis, thyroid disease, and disorders of the muscles. Results of these tests are normal in most people with fibromyalgia.
Doctors might diagnose fibromyalgia if you have pain in many parts of your body and they cannot find another cause. This is more likely if you also have other symptoms that can happen in fibromyalgia, such as trouble sleeping, feeling very tired, and trouble thinking clearly.
How is fibromyalgia treated?
There are medicines and strategies to help with the symptoms of fibromyalgia. But there is no 1 treatment that works for everyone. You and your health care team will need to work together to find the right mix of treatments for you. In general, treatment can include:
Medicines to relieve pain, improve sleep, or improve mood Physical therapy to learn exercises and stretches Relaxation therapy Working with a counselor
To get the best treatment, many people need a team that includes:
Should I take medicines?
In addition to exercise and coping techniques to help manage symptoms, many people with fibromyalgia benefit from medication. The medications that have been most effective in relieving symptoms of fibromyalgia in clinical trials are drugs that target chemicals in the brain and spinal cord that are important in processing pain. These include some of the medications usually used to treat depression (antidepressants) and epilepsy (anticonvulsants). By contrast, medications and techniques that work to decrease symptoms of pain locally, such as antiinflammatory drugs and analgesics, are less effective.
The best medication for you will depend on your symptoms, preferences, and cost concerns, as well as which drugs are available in your area. Your doctor can talk to you about options and how to begin medication therapy. In general, medication is usually started at a low dose and then increased slowly as needed.
Antidepressants — There are several different classes of drugs used to treat depression (see "Patient education: Depression treatment options for adults (Beyond the Basics)"). Some of these can be effective in treating fibromyalgia symptoms as well.
Often, more than one class of these drugs are used together. For example, a low dose of a serotonin-norepinephrine reuptake inhibitor would be taken in the morning and a low dose of a tricyclic antidepressant or another drug would be taken at bedtime.
Other drugs — You may wonder about other medications for treating your symptoms. However, evidence is limited, and it's important to talk with your doctor about your situation and what approach is most likely to help.
Fibromyalgia does not cause tissue inflammation; thus, neither nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (sample brand names: Advil, Motrin) or naproxen (sample brand name: Aleve) nor glucocorticoids (steroids) are effective in relieving fibromyalgia symptoms. (See "Patient education: Nonsteroidal antiinflammatory drugs (NSAIDs) (Beyond the Basics)".)
Analgesics (pain-relieving medications) are sometimes added to fibromyalgia medications for people who need additional short-term pain relief. They include acetaminophen (sample brand name: Tylenol) and the prescription medication tramadol (sample brand name: Ultram), which may be used alone or in combination. Tramadol is an opioid, although it is weaker than other opioid drugs and less likely to result in addiction. It may cause dizziness, diarrhea, or sleep disturbances in some people.
There is no evidence that long-term opioids are effective in treating fibromyalgia symptoms, and these drugs come with potentially serious side effects as well as a risk of addiction. Some people with fibromyalgia have reported that cannabis products, particularly cannabidiol (CBD), are helpful; however, this has not been studied sufficiently to confirm benefit and safety of these compounds. The Arthritis Foundation has urged the US Food and Drug Association (FDA) to expedite the study and regulation of cannabis for the treatment of fibromyalgia.
What are non-medication options?
Exercise — Regular exercise, such as walking, swimming, or biking, is helpful in reducing muscle pain and improving muscle strength and fitness in fibromyalgia. If you are beginning an exercise program for the first time, it's best to start slowly and gradually increase your level of activity. Over time, exercise typically improves fibromyalgia symptoms. Muscle strengthening programs also appear to improve pain, decrease the number of tender points, and improve muscle strength.
It can also help to work with a physical therapist to develop an appropriate, individualized exercise program that will be of most benefit to you. Eventually, a good goal is to exercise for at least 30 minutes three times weekly. A separate topic review discusses exercise and arthritis; some of these approaches may also help people with fibromyalgia. (See "Patient education: Arthritis and exercise (Beyond the Basics)".)
Relaxation therapies — In some cases, participating in stress-reduction programs, learning relaxation techniques, or participating in hypnotherapy (hypnosis), biofeedback, or cognitive behavioral therapy (CBT) may help to relieve certain symptoms. Of these approaches, the most is known about CBT.
CBT is based on the concept that people's perceptions of themselves and of their surroundings affect their emotions and behavior. The goal of CBT is to change the way you think about pain and to deal with illness more positively. CBT has been especially effective when combined with patient education and information, ie, learning about your disease and how to manage it.
Mind-body stress reduction (MBSR) programs have been effective in fibromyalgia. MBSR may be individual or as part of a group and may involve discussion, meditation, and other techniques, such as hypnosis and biofeedback. During biofeedback, patients use information about typically unconscious bodily functions, such as muscle tension or blood pressure, to help gain conscious control over such functions.
Tai chi and yoga — Some people with fibromyalgia benefit from a traditional Chinese exercise called tai chi (which combines mind-body practice with gentle, flowing movement exercises) or yoga.
Acupuncture — Acupuncture involves inserting hair-thin, metal needles into the skin at specific points on the body. It causes little to no pain. In some cases, a mild electric current is applied to the needle, termed electroacupuncture. Most studies have found acupuncture to be helpful but there has been little difference found between traditional and "sham" acupuncture.
Multidisciplinary therapy — Fibromyalgia typically responds best to an integrated management program, combining medications, exercise, and cognitive approaches. This works best if a team of health care professionals is involved.
Is there a link between fibromyalgia and COVID-19?
Although many chronic medical illnesses may have been exacerbated during the coronavirus disease 2019 (COVID-19) pandemic, patients with pre-existing fibromyalgia may be particularly vulnerable. Stress and social isolation adversely impact mood, including depression, and anxiety, as well as sleep disturbance, which are common symptoms in fibromyalgia.
There is also evidence that the COVID-19 pandemic has precipitated new cases of fibromyalgia. For example, chronic, unexplained widespread pain is common for months after the initial COVID-19 infection, a common symptom in what has been termed long COVID syndrome. Such patients often meet the clinical criteria for fibromyalgia.
Links to the PDFs on Google Drive:
Fibromyalgia: The Basics
Fibromyalgia: Beyond the Basics
submitted by BarbFunes to Fibromyalgia [link] [comments]
What is fibromyalgia?
Fibromyalgia is a condition that causes people to feel pain in the muscles and soft tissues all over their body. People with fibromyalgia also have many places on their body that hurt a lot when they are touched. No one knows what causes fibromyalgia.
Fibromyalgia is one of a group of chronic pain disorders that affect connective tissues, including the muscles, ligaments (the tough bands of tissue that bind together the ends of bones), and tendons (which attach muscles to bones). It is a chronic condition that causes widespread muscle pain (known as "myalgia") and extreme tenderness in many areas of the body. Many patients also experience fatigue, sleep disturbances, headaches, and mood disturbances such as depression and anxiety. Despite ongoing research, the cause, diagnosis, and optimal treatment of fibromyalgia are not clear.
In the United States, fibromyalgia affects about 2 percent of people by age 20, which increases to approximately 8 percent of people by age 70; it is the most common cause of generalized musculoskeletal pain in women between 20 and 55 years. It is more common in women than men.
What causes fibromyalgia?
The cause of fibromyalgia is unknown. Various physical or emotional factors (such as infection, injury, or stress) may play a role in triggering symptoms, although many patients report a lifelong history of chronic pain.
In people with fibromyalgia, the muscles and tendons are excessively irritated by various painful stimuli. This is thought to be due to a heightened perception of pain, a phenomenon called "central sensitization." Other conditions may also develop as a result of central sensitization, including irritable bowel syndrome (IBS); chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); chronic headaches; chronic pelvic and bladder pain; and chronic jaw and facial pain.
There is no generally agreed-upon explanation for how or why central sensitization develops in some people. The most plausible theory suggests that there is a genetic component, meaning that some people are predisposed to having a heightened sense of pain. People with a parent or sibling with fibromyalgia have a higher chance of developing it themselves. In some cases, various stressors, including infection (eg, Lyme disease or viral illness), diseases that involve joint inflammation (eg, rheumatoid arthritis or systemic lupus erythematosus), physical or emotional trauma, or sleep disturbances appear to trigger the development of fibromyalgia.
Brain imaging studies in people with fibromyalgia and related chronic pain disorders have shown changes in brain function and connections between different parts of the brain. As research continues, the factors that lead to chronic pain in fibromyalgia will be better understood, hopefully allowing for the development of better treatments.
Can fibromyalgia be cured?
In some people, fibromyalgia seems to get better. But in most people, it cannot be cured. Even so, people can learn to deal with the condition and lead fairly normal lives. Fibromyalgia does not get worse over time, and it is not life-threatening.
Does fibromyalgia cause symptoms besides muscle pain?
The primary symptom of fibromyalgia is widespread (or "diffuse"), chronic, and persistent pain. Although the pain is felt in muscles and soft tissues, there are no visible abnormalities in these areas. The pain may be described as a deep muscular aching, soreness, stiffness, burning, or throbbing. Patients may also feel numbness, tingling, or unusual "crawling" sensations in the arms and legs. Although some degree of muscle pain is always present, it varies in intensity and is aggravated by certain conditions, such as anxiety or stress, poor sleep, exertion, or exposure to cold or damp conditions. People often describe their muscle symptoms as feeling like they always have the flu.
The pain may be confined to specific areas, often the neck or shoulders, early in the course of the disease. Multiple regions are eventually involved, with most patients experiencing pain in the neck, middle and lower back, arms and legs, and chest wall. Areas called "tender points" can feel painful with even mild to moderate pressure. Many patients with fibromyalgia feel that their joints are swollen, although there is no visible inflammation of the joints (as would be found in forms of arthritis).
Persistent fatigue occurs in more than 90 percent of people with fibromyalgia. Most people complain of unusually light, unrefreshing, or nonrestorative sleep. Difficulties falling asleep, awakening repeatedly during the night, and feeling exhausted upon awakening are also common problems.
People with fibromyalgia may also have sleep apnea (when the person stops breathing for a few moments while sleeping) or restless legs syndrome (when there is an uncontrollable urge to move the legs). Like some painful conditions, these sleep problems might also be triggers of fibromyalgia. If you have one or both of these problems, your doctor will likely recommend a formal sleep evaluation to confirm the diagnosis
Many people with fibromyalgia also have depression and/or anxiety at the time of diagnosis, or develop one or both later in life. However, this is true of most chronic pain conditions, and fibromyalgia is not simply a physical manifestation of depression.
They can also have:
- Trouble thinking clearly
- Flu-like symptoms Headaches
- Depression and anxiety
- Stomach pain
- Too many or too few bowel movements (diarrhea or constipation)
- Pain in the bladder or the need to urinate in a hurry or often
- Problems with the jaw
Is there a test for fibromyalgia?
No, there is no test. To diagnose it, doctors and nurses review your symptoms. If you have symptoms of fibromyalgia, your doctor should obtain a medical history and do a physical exam to rule out arthritis, other connective tissue problems, neurologic conditions, and other disorders that may be causing your symptoms.
Routine laboratory tests may be recommended to help exclude certain conditions, such as inflammatory arthritis, thyroid disease, and disorders of the muscles. Results of these tests are normal in most people with fibromyalgia.
Doctors might diagnose fibromyalgia if you have pain in many parts of your body and they cannot find another cause. This is more likely if you also have other symptoms that can happen in fibromyalgia, such as trouble sleeping, feeling very tired, and trouble thinking clearly.
How is fibromyalgia treated?
There are medicines and strategies to help with the symptoms of fibromyalgia. But there is no 1 treatment that works for everyone. You and your health care team will need to work together to find the right mix of treatments for you. In general, treatment can include:
Medicines to relieve pain, improve sleep, or improve mood Physical therapy to learn exercises and stretches Relaxation therapy Working with a counselor
To get the best treatment, many people need a team that includes:
- A doctor
- A physical therapist
- Someone trained in mental health (such as a social worker or counselor)
Should I take medicines?
In addition to exercise and coping techniques to help manage symptoms, many people with fibromyalgia benefit from medication. The medications that have been most effective in relieving symptoms of fibromyalgia in clinical trials are drugs that target chemicals in the brain and spinal cord that are important in processing pain. These include some of the medications usually used to treat depression (antidepressants) and epilepsy (anticonvulsants). By contrast, medications and techniques that work to decrease symptoms of pain locally, such as antiinflammatory drugs and analgesics, are less effective.
The best medication for you will depend on your symptoms, preferences, and cost concerns, as well as which drugs are available in your area. Your doctor can talk to you about options and how to begin medication therapy. In general, medication is usually started at a low dose and then increased slowly as needed.
Antidepressants — There are several different classes of drugs used to treat depression (see "Patient education: Depression treatment options for adults (Beyond the Basics)"). Some of these can be effective in treating fibromyalgia symptoms as well.
- Tricyclic antidepressants (TCAs) – These drugs are often used first in treating fibromyalgia. Examples include amitriptyline and nortriptyline. Cyclobenzaprine, a closely related medication, may help in treating fibromyalgia but is not effective for depression. Taking TCAs before bedtime may promote deeper sleep and may alleviate muscle pain. Lower doses are usually used in fibromyalgia than the doses needed to treat depression, but even when taken at low doses, side effects are common; they may include dry mouth, fluid retention, weight gain, constipation, or difficulty concentrating.
- Dual-reuptake inhibitors – These drugs, also called serotonin-norepinephrine reuptake inhibitors (SNRIs), can help with symptoms of fibromyalgia as well. They include duloxetine and milnacipran. The most common side effects are nausea and dizziness, but these are generally more tolerable if the dose is started at a low level and is increased very slowly.
- Selective serotonin-reuptake inhibitors – Selective serotonin-reuptake inhibitors (SSRIs) such as fluoxetine and paroxetine may also be effective in fibromyalgia. However, they are not as effective for pain reduction as the tricyclic or dual-reuptake medications. SSRIs are not typically used as initial treatment of fibromyalgia, but doctors might try them in some situations. These are a group of antidepressant drugs that work to increase the concentration of serotonin in the brain. Serotonin is a naturally produced chemical that regulates the delivery of messages between nerve cells.
Often, more than one class of these drugs are used together. For example, a low dose of a serotonin-norepinephrine reuptake inhibitor would be taken in the morning and a low dose of a tricyclic antidepressant or another drug would be taken at bedtime.
Other drugs — You may wonder about other medications for treating your symptoms. However, evidence is limited, and it's important to talk with your doctor about your situation and what approach is most likely to help.
Fibromyalgia does not cause tissue inflammation; thus, neither nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen (sample brand names: Advil, Motrin) or naproxen (sample brand name: Aleve) nor glucocorticoids (steroids) are effective in relieving fibromyalgia symptoms. (See "Patient education: Nonsteroidal antiinflammatory drugs (NSAIDs) (Beyond the Basics)".)
Analgesics (pain-relieving medications) are sometimes added to fibromyalgia medications for people who need additional short-term pain relief. They include acetaminophen (sample brand name: Tylenol) and the prescription medication tramadol (sample brand name: Ultram), which may be used alone or in combination. Tramadol is an opioid, although it is weaker than other opioid drugs and less likely to result in addiction. It may cause dizziness, diarrhea, or sleep disturbances in some people.
There is no evidence that long-term opioids are effective in treating fibromyalgia symptoms, and these drugs come with potentially serious side effects as well as a risk of addiction. Some people with fibromyalgia have reported that cannabis products, particularly cannabidiol (CBD), are helpful; however, this has not been studied sufficiently to confirm benefit and safety of these compounds. The Arthritis Foundation has urged the US Food and Drug Association (FDA) to expedite the study and regulation of cannabis for the treatment of fibromyalgia.
What are non-medication options?
Exercise — Regular exercise, such as walking, swimming, or biking, is helpful in reducing muscle pain and improving muscle strength and fitness in fibromyalgia. If you are beginning an exercise program for the first time, it's best to start slowly and gradually increase your level of activity. Over time, exercise typically improves fibromyalgia symptoms. Muscle strengthening programs also appear to improve pain, decrease the number of tender points, and improve muscle strength.
It can also help to work with a physical therapist to develop an appropriate, individualized exercise program that will be of most benefit to you. Eventually, a good goal is to exercise for at least 30 minutes three times weekly. A separate topic review discusses exercise and arthritis; some of these approaches may also help people with fibromyalgia. (See "Patient education: Arthritis and exercise (Beyond the Basics)".)
Relaxation therapies — In some cases, participating in stress-reduction programs, learning relaxation techniques, or participating in hypnotherapy (hypnosis), biofeedback, or cognitive behavioral therapy (CBT) may help to relieve certain symptoms. Of these approaches, the most is known about CBT.
CBT is based on the concept that people's perceptions of themselves and of their surroundings affect their emotions and behavior. The goal of CBT is to change the way you think about pain and to deal with illness more positively. CBT has been especially effective when combined with patient education and information, ie, learning about your disease and how to manage it.
Mind-body stress reduction (MBSR) programs have been effective in fibromyalgia. MBSR may be individual or as part of a group and may involve discussion, meditation, and other techniques, such as hypnosis and biofeedback. During biofeedback, patients use information about typically unconscious bodily functions, such as muscle tension or blood pressure, to help gain conscious control over such functions.
Tai chi and yoga — Some people with fibromyalgia benefit from a traditional Chinese exercise called tai chi (which combines mind-body practice with gentle, flowing movement exercises) or yoga.
Acupuncture — Acupuncture involves inserting hair-thin, metal needles into the skin at specific points on the body. It causes little to no pain. In some cases, a mild electric current is applied to the needle, termed electroacupuncture. Most studies have found acupuncture to be helpful but there has been little difference found between traditional and "sham" acupuncture.
Multidisciplinary therapy — Fibromyalgia typically responds best to an integrated management program, combining medications, exercise, and cognitive approaches. This works best if a team of health care professionals is involved.
Is there a link between fibromyalgia and COVID-19?
Although many chronic medical illnesses may have been exacerbated during the coronavirus disease 2019 (COVID-19) pandemic, patients with pre-existing fibromyalgia may be particularly vulnerable. Stress and social isolation adversely impact mood, including depression, and anxiety, as well as sleep disturbance, which are common symptoms in fibromyalgia.
There is also evidence that the COVID-19 pandemic has precipitated new cases of fibromyalgia. For example, chronic, unexplained widespread pain is common for months after the initial COVID-19 infection, a common symptom in what has been termed long COVID syndrome. Such patients often meet the clinical criteria for fibromyalgia.
Links to the PDFs on Google Drive:
Fibromyalgia: The Basics
Fibromyalgia: Beyond the Basics
2023.03.30 19:45 Margotli Understanding Stem cell homing: From physiology to application in cellular therapeutics
 | submitted by Margotli to RegenerateEverything [link] [comments] |
2023.03.30 19:45 tonnie_taller Colorado boy attacked by shark on Cancun spring break vacation
A shark attacked a 10-year-old Colorado boy while he played knee-deep in the water during a family vacation in Cancun, Mexico. The shark was caught in a large wave and tore into Dillon Armijo’s leg on March 17, a family friend wrote on GoFundMe to help with medical bills and physical therapy. Armijo was airlifted … Continue reading Colorado boy attacked by shark on Cancun spring break vacation
submitted by tonnie_taller to Tonnie_Taller [link] [comments]
2023.03.30 19:41 EchoJobs Medtronic is hiring Sr Manufacturing Engineer Mexico Tijuana, Mexico [R]
![Medtronic is hiring Sr Manufacturing Engineer Mexico Tijuana, Mexico [R]](https://external-preview.redd.it/_v4bQCGOX38e5u6-NrQ3bdbz2HCE3eVQseTLucOFTwI.jpg?width=640&crop=smart&auto=webp&s=f782a3b9e0dabe34524c7b27e3b48cbe1a50b2f3 "Medtronic is hiring Sr Manufacturing Engineer Mexico Tijuana, Mexico [R]") | submitted by EchoJobs to rustjob [link] [comments] |
2023.03.30 19:40 sadiematt FEEDBACK WELCOME - Short story - The Enchanted Corner
A screw top corona. Not my first choice, but handed to me cold, so I wasn’t going to decline. An apartment party is not somewhere that I ventured too often, but I had just gotten back in town after a 4-month bender abroad, an annoying sentence, I know. Being apart from my friends, I was willing to oblige to their desired evening of fun. Drinking was not atop my priority list, but I was happy to be back with the crew.
It was summer in a sleepy college town. Not a lot to do and not a lot of places to find trouble, so to the apartment party we went, my half empty corona in hand.
Peter and I had met on Halloween 6 months prior to this evening. There was an instant connection. I have never cry laughed more or felt more myself than when I’m with him. Everyone loved Peter. What’s not to love? He made everyone feel like a friend, funny and witty, welcoming, and kind. Once I got to know him on a deeper level, I quickly realized that there was a sad part of him, and I think that is why we connected so well. We were the life of the party, but sad inside to no one’s wiser. We never talked about it, but I know one another’s company made us both feel at home. I quickly knew that I wanted this friendship to last forever. A week after we met, I knew I would have to let him know that I was not romantically interested in him so we could get on with being friends. At 22, a boy doesn’t want to hear that. Now, some 10 years later, he is thankful for the decision I made for us all those years ago. My older brother, my safe space.
Peter liked to party. It was not odd to go to a party with one another and end the night, separated (and by separated, I mean, Peter getting too drunk and leaving a party with out telling anyone or getting kicked out of a bar). We always found our way back to each other the next morning. Breakfast and a gossip session over the events of the night before.
You can hear the music and the beer pong from the ground floor. Peter and I enter the buzzing apartment. I immediately see an old friend that I have not seen since I’ve returned. I am elated. I run over to Thomas and smoother him in the biggest hug imaginable. His face lights up, shocked to see me. We hold up in a corner, laughing and swapping stories from the semester. Thomas and I have had every single class together since freshman year. Our classroom friendship, turned study buddies, turned into a real-life friendship outside of the hallways and the late-night papers. One of the most genuine people I had during college. I was so happy to be reunited. We had so much to catch up on.
Thomas was shy. He never had a ton to say, which is why we got along so well, I can’t shut up, and he’s a great listener. I think he liked how I just forced my friendship onto him, he didn’t really have a say in the matter. We were spending so much of our academic hours together, which made me want to be friends all of the time. He didn’t seem opposed, and we’ve been friends ever since. The extrovert adopts the introvert, a true match made.
I feel a tap on my shoulder. It’s a familiar face from freshman year. Matt. He was friends with some of my older friends. Nice guy, weird he was at this party. Hasn’t he graduated? I thought to myself.
“Sadie, how to hell are you girl”? he screamed into my ear as he embraced me. Matt was an enthusiastic guy. Happy about everything, until he got too drunk, and enthusiasm turned into extremely annoying, very quickly. We exchanged small talk, until we were approached by another figure.
“Chad, what the fuck is up man, come here. Do you know Sadie? Greatest girl on earth, you have to meet her”?! Matt yelled as he embraced Chad. I knew Chad. He had messaged me while I was away for the semester. A random message, considering I had been at my university for 3.5 years and never heard of him until his Instagram DM. I chalked it up to him hearing about my recent break up. It’s a small town, the dating pool is subpar, and we ran in different circles. I put two and two together, Thomas and Matt are in the same frat, and I’m now learning that that is how Chad fits into this circle. We spoke a couple times while I was away, nothing serious, and left it at “see ya around”. I guess “around” was happening right now.
“I am hopping to get to know her a lot more” Chad smirked. Matt turned to me and continued to tell me about awesome Chas is and how crazy it was that our paths have never crossed.
Everyone knew the answer to that. I had dated the same guy all of college, and up until a few months ago, I didn’t know who the cute, single guys were on campus. I quickly learned that Chad, was one of them. Maybe this was my chance to have a little fun as I entered my senior year. I was going to have an easy year and after a very bad break up, no strings attached fun was exactly what I needed.
“Let me get you a drink” Chad suggested. That’s right, my corona. I had finished it on the ride over here and was too busy talking with Thomas to get another. Chad appeared with a red solo cup of what he called “the house drink”. I took the half-filled cup and took a sip. It tasted like every other party juice that college kids make. Likely an entire bottle of cheap brunettes’ vodka and whatever juice they had in the fridge. I now find myself in another corner, completely enchanted with Chad.
I don’t know how much time has passed; I tell him I need to use the restroom. I push past the crowd of strangers and dodge flying ping pong balls. I find myself in a bathroom. I look at myself in the mirror. Am I having a good time? I ask myself with a smile. It’s been almost 4 years of college and the bad times have unfortunately clouded my memories of the fun times. At 21 years old, I find myself struggling with dark, overwhelming emotions that I have absolutely no idea how to navigate. It’s refreshing to be sober and having fun, especially with a cute boy. I kind of want to go home with Chad? If that’s what this leads to, I think as I wash my hands and reapply my lip gloss. He’s a 22 year old guy, of course he wants me to come home with him. I’ve never done that before. Gone home with someone I barley know? It’s college, I’m single, this is exactly what I can and want to do I think to myself as I place the lip gloss back into my bag.
Anyway, I need to get back out there. I toss the gross rag back onto the counter. Give my hair a fluff and open the door. Thomas is standing right outside the door as I open it. “Stop talking to him” he whispers to me. “What”? I screamed over the blaring music. Thomas mumbles when he’s been drinking so I have no idea what he’s getting on about. “That guy is bad news, just warning you” he says looking at me with the coldest stare he’s ever given. Thomas has never had an opinion on my dating or social life, ever. That’s the best thing about our friendship. It’s just a fun, healthy, no bad energy kind of flow. We don’t talk boys or girls and we can just be ourselves with each other. Hearing him say something about Chad is odd. “He’s nice, we’re just talking” I assure him and prance back to my corner.
I always wonder how different my life would be if Thomas was a girl. If a girlfriend told me to be worried about a guy and not talk to them, I would listen. I would have never gone back over to that guy. I trust my girlfriends with my life. In that moment, I thought Thomas was drunk and crushing on me and didn’t like seeing me with a guy that he deemed to be a “douche bag”. I always wonder if Matt didn’t see me that night, would Chad have even approached us talking. I always wonder if Peter didn’t want to go out that night, I would have never ended up in the apartment. I always wonder if I didn’t take a drink of that juice and vodka, the events of that night would have played out differently. I can’t ask myself those questions these days. I don’t handle “what ifs” very well.
I get back to my corner. I’m feeling flushed. It’s probably the juice in the drink, I’ve never liked a sweet drink. Makes my head hurt. Chad is almost as charming as I think I am. My charm comes in the form of sarcasm and dancing around the line of just being mean. Boys love that.
“I’m having a great time, I don’t even care that we’re at this party, do you want to maybe come back to my place and keep talking? I just live down the street” Chad leans into me closer as he asks with the most soft but confident tone. I don’t even think before I answer, an excited “Yes” slips from my glossed lips.
“My roommate is here actually; he doesn’t drink so he can drive us”. His roommate appears out of thin air, like he was a fly on the wall, waiting for his cue. It's like he had it planned.
I don’t tell Peter and Thomas I’m leaving. The last thing I want to hear from them is all the reasons I shouldn’t. I scan the room; Peter isn’t even in the apartment. Classic. Thomas must be in the room I left him in, I don’t say bye. I take Chad’s hand and we’re getting in his roommates’ car. He sits in the back with me, even though there isn’t a 4th person coming with us. I think it’s odd, making your roommate be your driver? I don’t think about it again. I’m dizzy. It’s probably the car, I do get car sick.
The roommate jumps out of the car before the head lights even turn off and heads inside, it’s like he was trying to run away from us. Again, odd. Maybe he’s just an awkward guy. We get up to his second-floor apartment. It’s a typical boy apartment. The TV to couch ratio is off and there are empty whiskey bottles lining the top of the kitchen counters. I roll my eyes.
Why am I here? My heart is racing out of my chest. I feel like I could run a marathon but, I can barely keep my eyes open. I’ve never felt like this before. I don’t even remember the car ride over here? Which is strange, considering I had 1 corona 2 hours ago and half a class of juicy vodka over the last hour. I keep doing “drink math” in head as it spins in circles. Trying to understand why this blanket of fog and discomfit comes over so quickly. I don’t want to get sick, how embarrassing would that be? Especially in front of this cute guy that I’ve just met.
He walks me into his room. We’re kissing. That’s fine. I sit down on the bed, his palms grabbing either side of my face. I’m good with that. I pull back, “I don’t want to have sex” I said nervously. I’m up front, I wanted him to know that that’s not why I came back here. I just wanted to see how things were, just the two of us. “Then we don’t have to” he smiled as he went back to kissing me.
Darkness. I can’t see anything. I know things are happening, I couldn’t tell you exactly what. Are my eyes even open? I’m trying to open them. I’m trying to talk. I can’t hear myself. It’s like all motor functions just slipped away without me knowing. Like I’m a baby that wants to communicate but can only make a few sounds. I can’t get my point across. It’s extremely frustrating. I can’t even tell if I can move my arms. Panic sets in. I hear an exhausted “NO” escape my lips. I think? I hope.
Darkness. I don’t know how much time has passed. Am I coming in and out of consciousness? I don’t even know what that feeling is like, I’ve never experienced what’s happening to me before. I’m in a bathroom? Why? I look up and see myself in the mirror. I’m naked. I tilt my head up a little further and I see him, behind me, naked as well.
He’s Inside of me. I realize what is happening.
Why are we in the bathroom? Did you need to watch me in the mirror? Did I run in here and you followed me to continue what you had started in the darkness.
“NO, get off me” finally. I heard that. It was loud. Good. I run back into the room. Why are my clothes off? Where is my purse? God why do I always wear so much jewelry, it’s everywhere. I can buy new stuff. No, this is new stuff, get it off the floor. I toss myself together, shoes and bag in hand. I run.
Darkness.
I’m on the phone.
Darkness.
Now, I’m in a car.
Darkness.
Now, I’m swallowing a pill, eating a taco, drinking water out of a glass, and laying in Monica’s bed. She seems very stressed out. How did I get here? I asked myself as I examine my familiar surroundings.
The next morning, we treated it like a normal morning.
Monica was my best friend. Looking back at our friendship, she was more like a mother. A mother with attachment issues. She was in and out of relationships or flings, always obsessing over the ex she dumped. She was an only child, selfishness came natural to her. She was only a couple years older than me. I thought she hung the moon. I had never had a friendship like this before. We were rarely apart. After my break up, I basically lived with Monica. I would have done anything for her, and to be honest, at that moment in time, she would have done anything for me. it’s the only time I had ever felt like she truly cared about me.
Peter and Jake met Monica and I at breakfast. Over the past 6 months, the 4 of us did everything together. We were the life of every party. They were the ying to our yang. This breakfast however, was not like our normal Sunday hungover gossip sessions.
“Are you going to tell them or should I”? Monica blurted out once we all got our drinks. I felt the redness flush over my cheeks. I couldn’t say that word. I couldn’t tell Peter what happened. I couldn’t look him in the eyes. I didn’t even want to tell Monica what happened. She told me she found me in a parking lot of an apartment building that we had never even been to before. She knew. I didn’t have to say anything. I wanted it to vanish out of my memory. I could barley remember anything so if I continued to push it out of my brain, it would be gone like a dream sooner rather than later.
I don’t remember the rest of that breakfast. I don’t remember the rest of that summer. If we’re being honest, looking back, I don’t remember most of college. It’s like that one night triggered something so dark inside of me that it erased everything from my memory. They call it trauma in therapy, but I call it protection.
Of course, I remember things here and there. Funny stories, my walks to class. But conversations, nights out with friends, the day-to-day life of what was supposed to be the greatest 4 years of your life was magically gone.
Not only did it trigger something dark inside of me, but it altered every cell in my body. The extrovert became an introvert. I couldn’t speak with a man with out a chip on my shoulder. I was moody and tired and completely unamused with everything. It’s like a was making poor decisions in my life on purpose because I was addicted to the pain and suffering. Sadness and shame were my new normal. I didn’t want to be happy, that felt like way too much work. I was good at being miserable.
I stayed like this for almost 3 years. I graduated, moved to a new city, made new friends, continued to make awful choices, got into another toxic relationship that wasn’t even a relationship and pushed away a lot of people. Monica and I had our inevitable break up. Thomas was still back in our college town, I didn’t see him often. Peter moved to the west coast the month before I moved to the east coast. An entire country apart. He still came to visit me. He checked on me. We missed each other so much, I know it hurt us both, but we would never tell each other. A simple “miss you” even though I knew it was more than that. I needed him. I needed someone there that loved me like I used to love myself.
submitted by sadiematt to WritersGroup [link] [comments]
It was summer in a sleepy college town. Not a lot to do and not a lot of places to find trouble, so to the apartment party we went, my half empty corona in hand.
Peter and I had met on Halloween 6 months prior to this evening. There was an instant connection. I have never cry laughed more or felt more myself than when I’m with him. Everyone loved Peter. What’s not to love? He made everyone feel like a friend, funny and witty, welcoming, and kind. Once I got to know him on a deeper level, I quickly realized that there was a sad part of him, and I think that is why we connected so well. We were the life of the party, but sad inside to no one’s wiser. We never talked about it, but I know one another’s company made us both feel at home. I quickly knew that I wanted this friendship to last forever. A week after we met, I knew I would have to let him know that I was not romantically interested in him so we could get on with being friends. At 22, a boy doesn’t want to hear that. Now, some 10 years later, he is thankful for the decision I made for us all those years ago. My older brother, my safe space.
Peter liked to party. It was not odd to go to a party with one another and end the night, separated (and by separated, I mean, Peter getting too drunk and leaving a party with out telling anyone or getting kicked out of a bar). We always found our way back to each other the next morning. Breakfast and a gossip session over the events of the night before.
You can hear the music and the beer pong from the ground floor. Peter and I enter the buzzing apartment. I immediately see an old friend that I have not seen since I’ve returned. I am elated. I run over to Thomas and smoother him in the biggest hug imaginable. His face lights up, shocked to see me. We hold up in a corner, laughing and swapping stories from the semester. Thomas and I have had every single class together since freshman year. Our classroom friendship, turned study buddies, turned into a real-life friendship outside of the hallways and the late-night papers. One of the most genuine people I had during college. I was so happy to be reunited. We had so much to catch up on.
Thomas was shy. He never had a ton to say, which is why we got along so well, I can’t shut up, and he’s a great listener. I think he liked how I just forced my friendship onto him, he didn’t really have a say in the matter. We were spending so much of our academic hours together, which made me want to be friends all of the time. He didn’t seem opposed, and we’ve been friends ever since. The extrovert adopts the introvert, a true match made.
I feel a tap on my shoulder. It’s a familiar face from freshman year. Matt. He was friends with some of my older friends. Nice guy, weird he was at this party. Hasn’t he graduated? I thought to myself.
“Sadie, how to hell are you girl”? he screamed into my ear as he embraced me. Matt was an enthusiastic guy. Happy about everything, until he got too drunk, and enthusiasm turned into extremely annoying, very quickly. We exchanged small talk, until we were approached by another figure.
“Chad, what the fuck is up man, come here. Do you know Sadie? Greatest girl on earth, you have to meet her”?! Matt yelled as he embraced Chad. I knew Chad. He had messaged me while I was away for the semester. A random message, considering I had been at my university for 3.5 years and never heard of him until his Instagram DM. I chalked it up to him hearing about my recent break up. It’s a small town, the dating pool is subpar, and we ran in different circles. I put two and two together, Thomas and Matt are in the same frat, and I’m now learning that that is how Chad fits into this circle. We spoke a couple times while I was away, nothing serious, and left it at “see ya around”. I guess “around” was happening right now.
“I am hopping to get to know her a lot more” Chad smirked. Matt turned to me and continued to tell me about awesome Chas is and how crazy it was that our paths have never crossed.
Everyone knew the answer to that. I had dated the same guy all of college, and up until a few months ago, I didn’t know who the cute, single guys were on campus. I quickly learned that Chad, was one of them. Maybe this was my chance to have a little fun as I entered my senior year. I was going to have an easy year and after a very bad break up, no strings attached fun was exactly what I needed.
“Let me get you a drink” Chad suggested. That’s right, my corona. I had finished it on the ride over here and was too busy talking with Thomas to get another. Chad appeared with a red solo cup of what he called “the house drink”. I took the half-filled cup and took a sip. It tasted like every other party juice that college kids make. Likely an entire bottle of cheap brunettes’ vodka and whatever juice they had in the fridge. I now find myself in another corner, completely enchanted with Chad.
I don’t know how much time has passed; I tell him I need to use the restroom. I push past the crowd of strangers and dodge flying ping pong balls. I find myself in a bathroom. I look at myself in the mirror. Am I having a good time? I ask myself with a smile. It’s been almost 4 years of college and the bad times have unfortunately clouded my memories of the fun times. At 21 years old, I find myself struggling with dark, overwhelming emotions that I have absolutely no idea how to navigate. It’s refreshing to be sober and having fun, especially with a cute boy. I kind of want to go home with Chad? If that’s what this leads to, I think as I wash my hands and reapply my lip gloss. He’s a 22 year old guy, of course he wants me to come home with him. I’ve never done that before. Gone home with someone I barley know? It’s college, I’m single, this is exactly what I can and want to do I think to myself as I place the lip gloss back into my bag.
Anyway, I need to get back out there. I toss the gross rag back onto the counter. Give my hair a fluff and open the door. Thomas is standing right outside the door as I open it. “Stop talking to him” he whispers to me. “What”? I screamed over the blaring music. Thomas mumbles when he’s been drinking so I have no idea what he’s getting on about. “That guy is bad news, just warning you” he says looking at me with the coldest stare he’s ever given. Thomas has never had an opinion on my dating or social life, ever. That’s the best thing about our friendship. It’s just a fun, healthy, no bad energy kind of flow. We don’t talk boys or girls and we can just be ourselves with each other. Hearing him say something about Chad is odd. “He’s nice, we’re just talking” I assure him and prance back to my corner.
I always wonder how different my life would be if Thomas was a girl. If a girlfriend told me to be worried about a guy and not talk to them, I would listen. I would have never gone back over to that guy. I trust my girlfriends with my life. In that moment, I thought Thomas was drunk and crushing on me and didn’t like seeing me with a guy that he deemed to be a “douche bag”. I always wonder if Matt didn’t see me that night, would Chad have even approached us talking. I always wonder if Peter didn’t want to go out that night, I would have never ended up in the apartment. I always wonder if I didn’t take a drink of that juice and vodka, the events of that night would have played out differently. I can’t ask myself those questions these days. I don’t handle “what ifs” very well.
I get back to my corner. I’m feeling flushed. It’s probably the juice in the drink, I’ve never liked a sweet drink. Makes my head hurt. Chad is almost as charming as I think I am. My charm comes in the form of sarcasm and dancing around the line of just being mean. Boys love that.
“I’m having a great time, I don’t even care that we’re at this party, do you want to maybe come back to my place and keep talking? I just live down the street” Chad leans into me closer as he asks with the most soft but confident tone. I don’t even think before I answer, an excited “Yes” slips from my glossed lips.
“My roommate is here actually; he doesn’t drink so he can drive us”. His roommate appears out of thin air, like he was a fly on the wall, waiting for his cue. It's like he had it planned.
I don’t tell Peter and Thomas I’m leaving. The last thing I want to hear from them is all the reasons I shouldn’t. I scan the room; Peter isn’t even in the apartment. Classic. Thomas must be in the room I left him in, I don’t say bye. I take Chad’s hand and we’re getting in his roommates’ car. He sits in the back with me, even though there isn’t a 4th person coming with us. I think it’s odd, making your roommate be your driver? I don’t think about it again. I’m dizzy. It’s probably the car, I do get car sick.
The roommate jumps out of the car before the head lights even turn off and heads inside, it’s like he was trying to run away from us. Again, odd. Maybe he’s just an awkward guy. We get up to his second-floor apartment. It’s a typical boy apartment. The TV to couch ratio is off and there are empty whiskey bottles lining the top of the kitchen counters. I roll my eyes.
Why am I here? My heart is racing out of my chest. I feel like I could run a marathon but, I can barely keep my eyes open. I’ve never felt like this before. I don’t even remember the car ride over here? Which is strange, considering I had 1 corona 2 hours ago and half a class of juicy vodka over the last hour. I keep doing “drink math” in head as it spins in circles. Trying to understand why this blanket of fog and discomfit comes over so quickly. I don’t want to get sick, how embarrassing would that be? Especially in front of this cute guy that I’ve just met.
He walks me into his room. We’re kissing. That’s fine. I sit down on the bed, his palms grabbing either side of my face. I’m good with that. I pull back, “I don’t want to have sex” I said nervously. I’m up front, I wanted him to know that that’s not why I came back here. I just wanted to see how things were, just the two of us. “Then we don’t have to” he smiled as he went back to kissing me.
Darkness. I can’t see anything. I know things are happening, I couldn’t tell you exactly what. Are my eyes even open? I’m trying to open them. I’m trying to talk. I can’t hear myself. It’s like all motor functions just slipped away without me knowing. Like I’m a baby that wants to communicate but can only make a few sounds. I can’t get my point across. It’s extremely frustrating. I can’t even tell if I can move my arms. Panic sets in. I hear an exhausted “NO” escape my lips. I think? I hope.
Darkness. I don’t know how much time has passed. Am I coming in and out of consciousness? I don’t even know what that feeling is like, I’ve never experienced what’s happening to me before. I’m in a bathroom? Why? I look up and see myself in the mirror. I’m naked. I tilt my head up a little further and I see him, behind me, naked as well.
He’s Inside of me. I realize what is happening.
Why are we in the bathroom? Did you need to watch me in the mirror? Did I run in here and you followed me to continue what you had started in the darkness.
“NO, get off me” finally. I heard that. It was loud. Good. I run back into the room. Why are my clothes off? Where is my purse? God why do I always wear so much jewelry, it’s everywhere. I can buy new stuff. No, this is new stuff, get it off the floor. I toss myself together, shoes and bag in hand. I run.
Darkness.
I’m on the phone.
Darkness.
Now, I’m in a car.
Darkness.
Now, I’m swallowing a pill, eating a taco, drinking water out of a glass, and laying in Monica’s bed. She seems very stressed out. How did I get here? I asked myself as I examine my familiar surroundings.
The next morning, we treated it like a normal morning.
Monica was my best friend. Looking back at our friendship, she was more like a mother. A mother with attachment issues. She was in and out of relationships or flings, always obsessing over the ex she dumped. She was an only child, selfishness came natural to her. She was only a couple years older than me. I thought she hung the moon. I had never had a friendship like this before. We were rarely apart. After my break up, I basically lived with Monica. I would have done anything for her, and to be honest, at that moment in time, she would have done anything for me. it’s the only time I had ever felt like she truly cared about me.
Peter and Jake met Monica and I at breakfast. Over the past 6 months, the 4 of us did everything together. We were the life of every party. They were the ying to our yang. This breakfast however, was not like our normal Sunday hungover gossip sessions.
“Are you going to tell them or should I”? Monica blurted out once we all got our drinks. I felt the redness flush over my cheeks. I couldn’t say that word. I couldn’t tell Peter what happened. I couldn’t look him in the eyes. I didn’t even want to tell Monica what happened. She told me she found me in a parking lot of an apartment building that we had never even been to before. She knew. I didn’t have to say anything. I wanted it to vanish out of my memory. I could barley remember anything so if I continued to push it out of my brain, it would be gone like a dream sooner rather than later.
I don’t remember the rest of that breakfast. I don’t remember the rest of that summer. If we’re being honest, looking back, I don’t remember most of college. It’s like that one night triggered something so dark inside of me that it erased everything from my memory. They call it trauma in therapy, but I call it protection.
Of course, I remember things here and there. Funny stories, my walks to class. But conversations, nights out with friends, the day-to-day life of what was supposed to be the greatest 4 years of your life was magically gone.
Not only did it trigger something dark inside of me, but it altered every cell in my body. The extrovert became an introvert. I couldn’t speak with a man with out a chip on my shoulder. I was moody and tired and completely unamused with everything. It’s like a was making poor decisions in my life on purpose because I was addicted to the pain and suffering. Sadness and shame were my new normal. I didn’t want to be happy, that felt like way too much work. I was good at being miserable.
I stayed like this for almost 3 years. I graduated, moved to a new city, made new friends, continued to make awful choices, got into another toxic relationship that wasn’t even a relationship and pushed away a lot of people. Monica and I had our inevitable break up. Thomas was still back in our college town, I didn’t see him often. Peter moved to the west coast the month before I moved to the east coast. An entire country apart. He still came to visit me. He checked on me. We missed each other so much, I know it hurt us both, but we would never tell each other. A simple “miss you” even though I knew it was more than that. I needed him. I needed someone there that loved me like I used to love myself.
2023.03.30 19:23 THSSFC Not a rhetorical question: Why can't Seattle / WA copy the Finnish "Housing First" model to combat homelessness?
Disclaimer: This is not one of those posts where the author really thinks the answer is known and is just phrasing the headline as a question to make a point. I really am interested in the barriers to adoption of this approach to reducing homelessness.
Background: Finland has steadily been reducing homelessness for over a decade by adopting a "housing first" policy. In short, this means that the FIRST intervention in homelessness is providing the sufferer with permanent housing. Not AFTER they undergo drug therapy, or gain employment, or any other hurdle. The first thing they get is a place to dwell. And it has reduced homelessness to about zero.
Here are a couple several articles on this approach, linked below for better understanding.
https://www.theguardian.com/cities/2019/jun/03/its-a-miracle-helsinkis-radical-solution-to-homelessness
https://oecdecoscope.blog/2021/12/13/finlands-zero-homeless-strategy-lessons-from-a-success-story/comment-page-1/
Some obvious concerns with this approach are:
Finland and WA are roughly the same size in population (we're about 1.5x the size) and WA's GDP is roughly 2x Finland, so we're both bigger and richer, but in the same general rank in size.
Is this a realistic model to pursue? Does this change if we can get the other West Coast states to participate in some sort of compact?
submitted by THSSFC to Seattle [link] [comments]
Background: Finland has steadily been reducing homelessness for over a decade by adopting a "housing first" policy. In short, this means that the FIRST intervention in homelessness is providing the sufferer with permanent housing. Not AFTER they undergo drug therapy, or gain employment, or any other hurdle. The first thing they get is a place to dwell. And it has reduced homelessness to about zero.
Here are a couple several articles on this approach, linked below for better understanding.
https://www.theguardian.com/cities/2019/jun/03/its-a-miracle-helsinkis-radical-solution-to-homelessness
https://oecdecoscope.blog/2021/12/13/finlands-zero-homeless-strategy-lessons-from-a-success-story/comment-page-1/
Some obvious concerns with this approach are:
- Cost: Counterbalanced by the reported reductions in other societal costs.
- Political continuity: The Finnish program has been continued unbroken for many years
- Political will: Will voters support a program that gives housing away for "free"?
- Geographical limits: Would this sort of program *attract* homeless from other parts of the country?
Finland and WA are roughly the same size in population (we're about 1.5x the size) and WA's GDP is roughly 2x Finland, so we're both bigger and richer, but in the same general rank in size.
Is this a realistic model to pursue? Does this change if we can get the other West Coast states to participate in some sort of compact?
2023.03.30 18:59 elastiks Magic TCR-T cell therapy: 72% of tumor lesions disappeared
 | submitted by elastiks to medical_trend [link] [comments] |
2023.03.30 18:26 NickShininger ATOS (Atossa Therapeutics) in depth DD 🚀
Listen up, apparently a lot of people give this stock crap because they got burned after it shot up to all time highs in 2021. However, this is why I see ATOS as an exciting investment into the future.
First, the company has over $100 million in cash with NO debt which is rare for a small cap pharma stock. It is currently trading below cash value ($.66 at the time this was written). They have a cash burn rate of approximately $5 million per quarter which allows them to continue operations without raising additional capital for years into the future.
The exciting part is that they have 3 separate Phase 2 trials going for their Z-Endoxifen. As a bit of background, Endoxifen is currently a part of Tamoxifen that is used to prevent and treat ER+ HER2 breast cancer. They recently had a separate Phase 2 trial cancelled early because results were so overwhelmingly positive. Endoxifen has the chance to replace Tamoxifen as the primary prevention and treatment drug for breast cancer as it has currently showed little to no side effects and a higher efficacy during the window of opportunity for prevention in both preclinical, phase 1 trials, and the phase 2 trial mentioned above.
The phase 2 trials they have ongoing is one in Sweden and two in the United States, with one recently being announced that it is being conducted with Quantum Leap Healthcare’s I-Spy trial focusing on advancing breast cancer research and bringing cancer drugs to market. Additionally, ATOS carries two patents now for Endoxifen so any other company that would want to use the drug would have to go to them first.
Lastly, ATOS recently bought 19% of Dynamic Cell Therapies which is a CAR-T focused, clinical trial company that addresses difficult-to-treat cancers. This will further help ATOS grow their pipeline and look into other opportunities for cancer treatment if needed.
The most exciting thing is that the CEO has stated multiple times that they plan on looking to be bought out after positive phase 2 trial results. Given the previous success with Endoxifen in earlier trials, I am confident that these Phase 2 trials will produce positive data and big pharma will be interested. The CEO already has 7 other FDA approved products on the market as well. The stock has been beaten down like many other bios as Phase 2 trials are ongoing and I believe it is a great opportunity to get in. GLTA.
Disclaimer: \This is not FA. For full transparency, my current position is 8600 shares at a .73 average.*
submitted by NickShininger to Shortsqueeze [link] [comments]
First, the company has over $100 million in cash with NO debt which is rare for a small cap pharma stock. It is currently trading below cash value ($.66 at the time this was written). They have a cash burn rate of approximately $5 million per quarter which allows them to continue operations without raising additional capital for years into the future.
The exciting part is that they have 3 separate Phase 2 trials going for their Z-Endoxifen. As a bit of background, Endoxifen is currently a part of Tamoxifen that is used to prevent and treat ER+ HER2 breast cancer. They recently had a separate Phase 2 trial cancelled early because results were so overwhelmingly positive. Endoxifen has the chance to replace Tamoxifen as the primary prevention and treatment drug for breast cancer as it has currently showed little to no side effects and a higher efficacy during the window of opportunity for prevention in both preclinical, phase 1 trials, and the phase 2 trial mentioned above.
The phase 2 trials they have ongoing is one in Sweden and two in the United States, with one recently being announced that it is being conducted with Quantum Leap Healthcare’s I-Spy trial focusing on advancing breast cancer research and bringing cancer drugs to market. Additionally, ATOS carries two patents now for Endoxifen so any other company that would want to use the drug would have to go to them first.
Lastly, ATOS recently bought 19% of Dynamic Cell Therapies which is a CAR-T focused, clinical trial company that addresses difficult-to-treat cancers. This will further help ATOS grow their pipeline and look into other opportunities for cancer treatment if needed.
The most exciting thing is that the CEO has stated multiple times that they plan on looking to be bought out after positive phase 2 trial results. Given the previous success with Endoxifen in earlier trials, I am confident that these Phase 2 trials will produce positive data and big pharma will be interested. The CEO already has 7 other FDA approved products on the market as well. The stock has been beaten down like many other bios as Phase 2 trials are ongoing and I believe it is a great opportunity to get in. GLTA.
Disclaimer: \This is not FA. For full transparency, my current position is 8600 shares at a .73 average.*
2023.03.30 18:24 WhileSerious What would you say to someone entering late 20s and feeling behind?
I turned 27 recently and I am experiencing a quarter life crisis and feel overwhelmed with panic attacks. I am in therapy.
I have a college degree, no debt, about $90k in savings between retirement and other accounts, and live on my own but getting a roommate soon. I recognize this privilege but I still feel panic and I am not sure where it stems from. It seems everyone is getting married and engaged and seem to have their absolute dream job or buying houses. I am comparing myself a lot and it is making me depressed. I don't usually compare myself so much. I'm scared I made wrong decisions that will impact the rest of my life. I tend to have this black or white mentality and I want to try to get some more perspective.
I am scared of being alone in life and have this sense of fear of time running out.
submitted by WhileSerious to findapath [link] [comments]
I have a college degree, no debt, about $90k in savings between retirement and other accounts, and live on my own but getting a roommate soon. I recognize this privilege but I still feel panic and I am not sure where it stems from. It seems everyone is getting married and engaged and seem to have their absolute dream job or buying houses. I am comparing myself a lot and it is making me depressed. I don't usually compare myself so much. I'm scared I made wrong decisions that will impact the rest of my life. I tend to have this black or white mentality and I want to try to get some more perspective.
I am scared of being alone in life and have this sense of fear of time running out.
2023.03.30 18:23 FlyingButterPerplex Special Education?
My son has only a few words at ~28 months (he's saying "mama" and "dada", he's said a few others in the past). We took him to be evaluated for early intervention and they evaluated him as having a mild delay for everything except for speech & language, for which he has a severe delay. He was a little shy around the evaluators and I felt a little on the spot answering the evaluators' questions, which were subjective. For instance, they asked whether he points to cars and planes. Since he's not really into cars, he usually ignores them. But, afterwards, I remembered that he does sometimes point at planes and makes a little flying "plane" with his hand (he's done this ever since my husband did it with relevant sound effects). My husband didn't mention it because it's a little subjective (he doesn't always point at planes) and we wanted to be sure he qualified for EI. He's a very sweet boy: for example, he waits his turn to go down the slide at a playground (some kids twice his age don't do that). He's interested in other kids. Nevertheless, he has some autistic traits (he is very sensitive to sound, occasionally toe walks (5-10% of the time or less), likes spinning around, etc).
But the evaluators checked something like "intellectual disability" on the form and that bothers me. I know, every parent wants to think their child is smart, but I just don't feel it is likely little guy will grow up intellectually disabled. In other words, I think he's likely on a different developmental schedule. If he were placed in a special ed track, this might negatively affect his future (where he would go to college, etc). And my understanding is that intellectual disability in adults is mostly genetic: both mom and dad are successful STEM PhDs who are intellectually able. I am not aware of anyone in our family being ID. Dad's IQ is in the gifted range and mine is probably too, though I've never had it tested. Grandpa (on dad's side) is also a successful STEM PhD (think of the top STEM university in the world... you probably thought of the one grandpa went to). My pregnancy was full term with no complications. We did genetic screening after I got pregnant and my little one is normal. Lead was not detected in his blood. We are planning to send him to an audiologist soon and maybe also an ENT and neurologist.
What would be the benefit of placing him into special ed if he will grow out of it? We are prepared to pay for speech therapy or anything else he needs in the meantime. If it turns out he is ID at age 7 or so, can't we put him in special ed then? Also, what would be the benefit of diagnosing him with autism (if he is autistic)? Grandpa (mentioned above) had to repeat a grade, dad talked late, and I also started talking after 24 months.
submitted by FlyingButterPerplex to speechdelays [link] [comments]
But the evaluators checked something like "intellectual disability" on the form and that bothers me. I know, every parent wants to think their child is smart, but I just don't feel it is likely little guy will grow up intellectually disabled. In other words, I think he's likely on a different developmental schedule. If he were placed in a special ed track, this might negatively affect his future (where he would go to college, etc). And my understanding is that intellectual disability in adults is mostly genetic: both mom and dad are successful STEM PhDs who are intellectually able. I am not aware of anyone in our family being ID. Dad's IQ is in the gifted range and mine is probably too, though I've never had it tested. Grandpa (on dad's side) is also a successful STEM PhD (think of the top STEM university in the world... you probably thought of the one grandpa went to). My pregnancy was full term with no complications. We did genetic screening after I got pregnant and my little one is normal. Lead was not detected in his blood. We are planning to send him to an audiologist soon and maybe also an ENT and neurologist.
What would be the benefit of placing him into special ed if he will grow out of it? We are prepared to pay for speech therapy or anything else he needs in the meantime. If it turns out he is ID at age 7 or so, can't we put him in special ed then? Also, what would be the benefit of diagnosing him with autism (if he is autistic)? Grandpa (mentioned above) had to repeat a grade, dad talked late, and I also started talking after 24 months.
2023.03.30 18:09 zbexbj Every time me have a minor row, my boyfriend (31M) puts it down to my (31F) mental health and tells me I need to go to therapy
I've been with my boyfriend for almost 2 years we have an amazing relationship, really respect each other, and are both sure we want to spend our lives together.
However, we keep getting into really long and emotional discussions which stem from what are initially just slight disagreements. I think it stems from the fact that I had a really bad bout of anxiety and depression at the end of last year. I was struggling to get out of bed, spent a lot of time crying, and often cut myself out of despair. He was amazing at dealing with it and really supportive.
After doing 5 months of CBT, I feel really good most of the time now. However, I now feel like my boyfriend puts every negative emotion I have down to my mental health. Few examples - I got socially anxious about having friends round for dinner, I got a bit annoyed with him for buying bad quality meat one time, and I got annoyed because he said something harsh to me in front of his friends. Now, I'm not absolving myself of blame and I accept that sometimes I overreact and am over-sensitive. However, what I find frustrating is that those conversations all spiraled away from the initial situation. They led to big meta conversations in which he accused me of not having taken therapy seriously the first time around and told me I need to go back again. This is the common theme.
I find it upsetting when he says that sort of thing because I put so much time and emotional effort into getting better. I went from having suicidal thoughts to living a basically normal life and my therapist also agreed it was time to stop the sessions. So his responses feel a bit condescending, like he doubts the work I've done, and doesn't trust me when I say that I am doing well now.
Any advice?
submitted by zbexbj to relationship_advice [link] [comments]
However, we keep getting into really long and emotional discussions which stem from what are initially just slight disagreements. I think it stems from the fact that I had a really bad bout of anxiety and depression at the end of last year. I was struggling to get out of bed, spent a lot of time crying, and often cut myself out of despair. He was amazing at dealing with it and really supportive.
After doing 5 months of CBT, I feel really good most of the time now. However, I now feel like my boyfriend puts every negative emotion I have down to my mental health. Few examples - I got socially anxious about having friends round for dinner, I got a bit annoyed with him for buying bad quality meat one time, and I got annoyed because he said something harsh to me in front of his friends. Now, I'm not absolving myself of blame and I accept that sometimes I overreact and am over-sensitive. However, what I find frustrating is that those conversations all spiraled away from the initial situation. They led to big meta conversations in which he accused me of not having taken therapy seriously the first time around and told me I need to go back again. This is the common theme.
I find it upsetting when he says that sort of thing because I put so much time and emotional effort into getting better. I went from having suicidal thoughts to living a basically normal life and my therapist also agreed it was time to stop the sessions. So his responses feel a bit condescending, like he doubts the work I've done, and doesn't trust me when I say that I am doing well now.
Any advice?
2023.03.30 18:01 MomentoMori1963 A path forward - who's in?
I suspect that many of us, myself included, have been on the "more is better" use of red lights without taking in account the research that supports the use of red lights. For more than a year on an irregular basis, I've turned on to full blast the 630nm and 820nm lamps my devices provided and then laid on my side with my back to them for 20-30 minutes and no regards for the distance and what amount of red light I was receiving. Just idiotic and naive of me.
As an initial better understanding and having searched the forum for terms like biphasic and Arndt-Shulz I believe I am not the only blaster here. Here's what I think is important to using these devices to the highest benefit.
"Infrared and Skin: Friend or Foe" the author offers that lower irradiance <50 mW/cm^2 is less likely to induce detrimental effects. (1)
Irradiance from 5 to 50 mW/cm^2 is generally used for stimulation and healing, while higher irradiances can be more for nerve inhibition and pain relief. (7)
A dose of 3 J/cm2 was significantly more effective when delivered at 5mW/cm^2 than 50mW/cm2. It performed the same as 30 J/cm2 delivered by 50mW/cm^2. Indicating that the duration of treatment also plays a role. (2)
When treatments are administered too closely together, the cumulative dose can reach an inhibitory range. (6) This could even mean that in the first days of treatment could have a beneficial effect and then cross over into a biphasic region. (7)
A 12-week study, understanding that the effects of PBM in muscle tissue lasts up to 48 hours, chose to use a low intensity of 8.1 mW/cm^2 for 15 seconds per treatment, 3 times a week. They cautiously designed a low dose to avoid the cumulative biphasic dose. And they were right, this course of treatment improved overall muscle fitness versus the placebo! (9)
The application of 5 J/cm2 with 4 mW/cm^2 had a significant effect on wound tensile strength, while the same dose delivered at 15 mW/cm^2 had no effect. (7)
The dose required to promote a therapeutic response is <10mW/cm^2, a dose 100 times this amount was found to have detrimental neuronal effect in mice. (4)
Hart et al. were so concerned about high dose biphasic response for brain PBM, that they were considering the additional exposure from Sunlight on patients adversely affecting clinical trials. (3)
Human stem cells had a peak response at 3 J/cm^2 with 16 mW/cm^2, where higher doses had diminished benefits. (5)
One study on collagen production found that medium irradiances and exposure durations were effective - 1.2 mW/cm^2 for 145 sec. (1)
---------------------------------------------------------------------------------------------------------------------------------------------
I strongly believe in the collective IQ of the group and open and transparent discussion of the facts, data, and science of red light therapy.
A good first step would be to see what people are needing/wanting to use RLT by creating a survey and then taking the most popular application desired to review and discuss the papers in the database to find the sweet spot just to the left of the peak of the Ardnt-Shulz curve for that application.
Over time, we can slowly work our way down the list and create a set of best practices for RLT. Who's in?
submitted by MomentoMori1963 to redlighttherapy [link] [comments]
As an initial better understanding and having searched the forum for terms like biphasic and Arndt-Shulz I believe I am not the only blaster here. Here's what I think is important to using these devices to the highest benefit.
- Have a device that does no harm. It's documented and 3rd party tested or independently reviewed to have the right wavelength(s) of light, the rated power, and little to no EMR and sufficient power to accomplish in a reasonable amount of time the irradiance cited in the studies being used to generate the same benefit.
- Find the sweet spot for exposure that keeps one on the left side of the Arndt-Shulz curve from more recent human in-vivo studies that have a control group as the highest weighted evidence. It is imperative that users avoid being overexposed and receiving a biphasic dose as the right side is very steep.
- Consider strategies like using a dental x-ray blanket or other materials to target areas while leaving others unaffected. An example might be using red light for kidneys may need more time and power than using for the heart. In such an application, you'd want to alternatively shield areas of your body to get the effect needed.
- There isn't a one size fits all level, duration, frequency, etc for use of red light. Just look at the variation cited in this article and in the PBM database. https://gembared.com/blogs/musings/the-skinny-on-intensity-effective-intensity-versus-high-intensity
"Infrared and Skin: Friend or Foe" the author offers that lower irradiance <50 mW/cm^2 is less likely to induce detrimental effects. (1)
Irradiance from 5 to 50 mW/cm^2 is generally used for stimulation and healing, while higher irradiances can be more for nerve inhibition and pain relief. (7)
A dose of 3 J/cm2 was significantly more effective when delivered at 5mW/cm^2 than 50mW/cm2. It performed the same as 30 J/cm2 delivered by 50mW/cm^2. Indicating that the duration of treatment also plays a role. (2)
When treatments are administered too closely together, the cumulative dose can reach an inhibitory range. (6) This could even mean that in the first days of treatment could have a beneficial effect and then cross over into a biphasic region. (7)
A 12-week study, understanding that the effects of PBM in muscle tissue lasts up to 48 hours, chose to use a low intensity of 8.1 mW/cm^2 for 15 seconds per treatment, 3 times a week. They cautiously designed a low dose to avoid the cumulative biphasic dose. And they were right, this course of treatment improved overall muscle fitness versus the placebo! (9)
The application of 5 J/cm2 with 4 mW/cm^2 had a significant effect on wound tensile strength, while the same dose delivered at 15 mW/cm^2 had no effect. (7)
The dose required to promote a therapeutic response is <10mW/cm^2, a dose 100 times this amount was found to have detrimental neuronal effect in mice. (4)
Hart et al. were so concerned about high dose biphasic response for brain PBM, that they were considering the additional exposure from Sunlight on patients adversely affecting clinical trials. (3)
Human stem cells had a peak response at 3 J/cm^2 with 16 mW/cm^2, where higher doses had diminished benefits. (5)
One study on collagen production found that medium irradiances and exposure durations were effective - 1.2 mW/cm^2 for 145 sec. (1)
---------------------------------------------------------------------------------------------------------------------------------------------
I strongly believe in the collective IQ of the group and open and transparent discussion of the facts, data, and science of red light therapy.
A good first step would be to see what people are needing/wanting to use RLT by creating a survey and then taking the most popular application desired to review and discuss the papers in the database to find the sweet spot just to the left of the peak of the Ardnt-Shulz curve for that application.
Over time, we can slowly work our way down the list and create a set of best practices for RLT. Who's in?
2023.03.30 17:58 Ok_Addition2144 Someone explain to me who the fuck actually believes this bullshit💀
 | submitted by Ok_Addition2144 to Ningen [link] [comments] |
2023.03.30 17:27 ViceVersaMedia My grandmother [65F] constantly talks shit about my stepsister [18F], and it’s becoming harder to hold my tongue
She basically doesn’t like her because she has social anxiety. She didn’t speak to her when they first met or something, and she’s had a sour impression of her ever since. But it has extended beyond a general dislike. She rants about her almost DAILY, sometimes for hours. She often just brings her up randomly or when the conversation originally had nothing to do with her. The rhetoric is borderline hateful
I’m honestly about one more rant away from snapping on her, because everything she criticizes her for is what she’d say about me if my circumstances were different (no fancy tech job or “acceptable” STEM degree). Not to mention that I [23M] personally suffer from social anxiety/depression that she barely respects as is.
submitted by ViceVersaMedia to TrueOffMyChest [link] [comments]
- Calls her lazy because she lays in bed most of the day (my first thought is depression)
- Implies that she’s stupid because she’s not planning to major in STEM, and that her grades (3.5 GPA) are just average because she shies away from “hard” classes
- Even acknowledges that she may be depressed and says she needs to cure it by getting a job, not therapy
I’m honestly about one more rant away from snapping on her, because everything she criticizes her for is what she’d say about me if my circumstances were different (no fancy tech job or “acceptable” STEM degree). Not to mention that I [23M] personally suffer from social anxiety/depression that she barely respects as is.
2023.03.30 17:17 RemarkableTie4641 Looking for advice.
Hello guys. I’m trying to see if someone can understand me and give me some advice. About a year ago I was backpacking in Mexico, I had a heavy backpack, probably around 9kg, and was giving me some trouble. A friend of mine told me my backpack was too tight and that I should lose it up a bit. I did that but I ended up carrying a really loose backpack. Like I was wearing it in a really bad way. By the next day I had really bad pain. When I came back to my country I had an mri and It show a dessicated disc (l5 s1) with an annular tear. I’ve had this pain for over a year now. It’s hard to sit for more than an hour. I’m only 26 and I’ve got really bad depression over this. Everyone else is doing their life’s and I’m kinda of stuck with this. Also, one of the worst part of this is the guilt I deal with, because I did this to myself, just because I didn’t listen to my body, also I’m really upset at my friend sometimes, because he was the one that told me to carry my backpack that way, and when he saw that I was carrying it the wrong way he didn’t say anything to me. Of course I know he didn’t mean for this to happen but I can help feeling this way. I just want to go back to not feeling pain. I wanna have a normal life, I wanna make music and I sometime wanna have a family. Please, if someone can offer some advice I would really appreciate it. I’ve tried pt, gym, and I’m willing to try stem cells and even adr. All my love to those suffering, you’re not alone.
submitted by RemarkableTie4641 to backpain [link] [comments]
2023.03.30 17:12 rashtibuticn98 Coeptis Therapeutics Secures Exclusive Rights to Negotiate to Acquire Transformational Cell Therapy Platform
Hey everyone, I was just reading about Coeptis Therapeutics and their exciting acquisition plans for VyGen-Bio. As someone who's been keeping an eye on the biopharmaceutical sector, I'm thrilled to see this kind of growth and innovation. It's always exciting to see companies investing in cutting-edge technology that could make a real difference in the lives of patients.
Summary:
Coeptis Therapeutics is a biopharmaceutical company that's been making waves in the industry lately, thanks to its innovative cell therapy platforms for cancer. In this article, we learn about the company's plans to acquire VyGen-Bio, a move that could expand Coeptis' capabilities even further. VyGen-Bio's product candidates and platforms were developed by scientists at the Karolinska Institutet in Sweden, and if the acquisition is successful, Coeptis would be in a great position to advance the development of various GEAR-engineered cells, which could be used in combination with mAbs to treat a broad range of hematologic malignancies and solid tumors.
Highlighted Main Points:
· Coeptis Therapeutics is a biopharmaceutical company that's focused on developing innovative cell therapy platforms for cancer.
· The company has announced its plans to acquire VyGen-Bio, a move that could expand Coeptis' capabilities even further.
· If the acquisition is successful, Coeptis would be able to advance the development of various GEAR-engineered cells, which could be used in combination with mAbs to treat a broad range of hematologic malignancies and solid tumors.
TLDR:
Coeptis Therapeutics is set to acquire VyGen-Bio, a move that could significantly expand the company's capabilities in the development of innovative cell therapy platforms for cancer, particularly the use of GEAR-engineered cells. This is great news for Coeptis and for patients who may benefit from these cutting-edge therapies.
READ MORE HERE:
https://finance.yahoo.com/news/coeptis-therapeutics-secures-exclusive-rights-134500044.html
submitted by rashtibuticn98 to wallstreetbets2 [link] [comments]
Summary:
Coeptis Therapeutics is a biopharmaceutical company that's been making waves in the industry lately, thanks to its innovative cell therapy platforms for cancer. In this article, we learn about the company's plans to acquire VyGen-Bio, a move that could expand Coeptis' capabilities even further. VyGen-Bio's product candidates and platforms were developed by scientists at the Karolinska Institutet in Sweden, and if the acquisition is successful, Coeptis would be in a great position to advance the development of various GEAR-engineered cells, which could be used in combination with mAbs to treat a broad range of hematologic malignancies and solid tumors.
Highlighted Main Points:
· Coeptis Therapeutics is a biopharmaceutical company that's focused on developing innovative cell therapy platforms for cancer.
· The company has announced its plans to acquire VyGen-Bio, a move that could expand Coeptis' capabilities even further.
· If the acquisition is successful, Coeptis would be able to advance the development of various GEAR-engineered cells, which could be used in combination with mAbs to treat a broad range of hematologic malignancies and solid tumors.
TLDR:
Coeptis Therapeutics is set to acquire VyGen-Bio, a move that could significantly expand the company's capabilities in the development of innovative cell therapy platforms for cancer, particularly the use of GEAR-engineered cells. This is great news for Coeptis and for patients who may benefit from these cutting-edge therapies.
READ MORE HERE:
https://finance.yahoo.com/news/coeptis-therapeutics-secures-exclusive-rights-134500044.html
2023.03.30 17:00 _call-me-al_ [Thu, Mar 30 2023] TL;DR — This is the top investing content you missed in the last 24 hours on Reddit
stocks
Found a paper stock certificate while cleaning. Is it worth anything?Comments Link
Electronic Arts is cutting about 800 jobs, or 6% of workforce, and reducing office space
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Goldman Sachs: U.S. consumer sentiment is deteriorating rapidly
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StockMarket
$150 Billion Tax Fraud & Money Laundering SchemeComments Link
This got me😂😂
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BREAKING: China & Brazil have agreed to trade in their own currencies, ditching the US dollar.
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investing
Big fall in Spain's CPI for march.Comments Link
Where are T-Bills headed?
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Uncorrelated assets S&P500
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trakstocks
Interesting News: Acquisition Rights Obtained for Immuno-Oncology Treatments Using CAR T Technology, Cell Therapy for Cancers (NASDAQ: COEP)Comments Link
I’m embracing this opportunity and finding the positives , that right now I’m able to accumulate a lot of shares and reduce my average. Some day soon all the pain will be worth all the gain and I have faith and it cannot be broken !
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Element79: High-Grade Gold Project with Near-Term Cash Flow Potential (CSE : ELEM, OTC: ELMGF)
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UndervaluedStonks
wallstreetbets
Credit Suisse whistleblowers say Swiss bank has been helping wealthy Americans dodge U.S. taxes for yearsComments Link
It’s been quiet, too quiet…
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JPow has a word for the bulls
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market_sentiment
Let’s say for $25,000 you could buy a 10% interest in the income of any one of your classmates that you wanted to. Would you do it?Comments Link
options
Trading ATM puts on small cap tech stocks after a bull run from external catalysts?Comments Link
Has anyone following PYPL option closely?
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How is volatility calculated in Cox-Ross-Rubinstein model?
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pennystocks
You only have to be right once. That is all.Comments Link
$GMZP - The Hottest Merger Play Currently in OTC; Here's Why
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MULN starts delivery to Randy Marion (confirmed)
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SecurityAnalysis
Jim Chanos: A Short Thesis on Data CentersComments Link
China grants billions in bailouts as Belt and Road Initiative falters…
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Valuation of Adobe + Figma
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Biotechplays
VIR BiotechnologyComments Link
algotrading
Alternative BrokersComments Link
Collecting and cleaning data for Renko brick strategies
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TDA Time and Sales?
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Forex
March P/LComments Link
If you don't sleep well, then something must be incredibly wrong with your risk management. Go fix it. Heart issues ain't a joke
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Trade 006 - Net Profits = 233.95 USD in 50 Minutes - GBPUSD with Trade Balancers
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RobinHood
Stock Market Recap for Wednesday, March 29, 2023Comments Link
CryptoMarkets
SEC Chair Gary Gensler to Face Questions on Approach towards the Crypto RegulationComments Link
CryptoCurrency on Reddit: China, Brazil strike deal to ditch dollar for trade
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Anyone feel like this XRP case is not going to go the way we think??
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2023.03.30 16:58 iluvtijuanna Not gonna lie I love smashing trans rite now and.they are hot in Tijuana Mexico
 | 80 % straight males low key smashing them for real Low key lol submitted by iluvtijuanna to TijuanaZonaNorteClubs [link] [comments] |
2023.03.30 16:53 darksynth1989 Any DACA people here with a psychological disorder?
just want to ask if any DACA people here have been diagnosed with a psychological disorder?
I was doing great, my business was doing good. In college and everything. I thought I was finally on the right path.
Then I started to feel sick went to the DR. Long story short after about a year I got diagnosed with a psychological disorder.
I couldn’t keep up with work, school. I fell behind. the money I had saved ran out then I started accumulating credit card debt. Everything started to go down hill.
Now I’m in therapy every week and on medication. I still feel like caca half the time and I feel like I can’t progress. You know that same feeling before we had DACA. That feeling or thought of not advancing in life.
There are times I get suicidal thoughts not because everything went to doodoo but because how mentally and physically sick I feel sometimes. There were also days I felt like asking for financial help as I felt so defeated but one thing I have a hard time with is asking for help, some of it stems from before daca were everywhere I looked for help there really wasn’t any so I don’t look for any anymore thinking there is no help.
Today my mind is clear and I feel like I have a normal day and it’s been so long I didn’t know how it felt to feel normal again.
Sorry guys just a rant, anyone else dealing with mental health issues just know you are not alone.
submitted by darksynth1989 to DACA [link] [comments]
I was doing great, my business was doing good. In college and everything. I thought I was finally on the right path.
Then I started to feel sick went to the DR. Long story short after about a year I got diagnosed with a psychological disorder.
I couldn’t keep up with work, school. I fell behind. the money I had saved ran out then I started accumulating credit card debt. Everything started to go down hill.
Now I’m in therapy every week and on medication. I still feel like caca half the time and I feel like I can’t progress. You know that same feeling before we had DACA. That feeling or thought of not advancing in life.
There are times I get suicidal thoughts not because everything went to doodoo but because how mentally and physically sick I feel sometimes. There were also days I felt like asking for financial help as I felt so defeated but one thing I have a hard time with is asking for help, some of it stems from before daca were everywhere I looked for help there really wasn’t any so I don’t look for any anymore thinking there is no help.
Today my mind is clear and I feel like I have a normal day and it’s been so long I didn’t know how it felt to feel normal again.
Sorry guys just a rant, anyone else dealing with mental health issues just know you are not alone.
2023.03.30 16:44 30yearsofsaltypain Title 42 dropping MAY 11th, we will be getting a surge of migrants
After border arrivals spiked in late 2022, Mr. Biden announced an overhaul of his administration's strategy to manage migration in early January. To deter illegal crossings, officials increased the number of countries whose citizens could be swiftly turned back to Mexico under Title 42 if they entered the U.S. unlawfully.
Mr. Biden's recent strategy has taken credit for a drop in the number of migrants attempting to enter the U.S. illegally across the Rio Grande
THIS IS DROP TAKES PLACE EVERY YEAR IN LATE DECEMBER, JANUARY as explained by Mr. Zoley Q4 2022 conference call.
ALSO THE DROP APPEARS MORE PROFOUND BECAUSE THE (ABNORMAL) SURGE IN LATE 2022 WAS QUITE HIGH...MAKING THE DROP LOOK MORE IMPRESSIVE.
The numbers have been ticking up again in March and are now heading towards a surge in April,May, June. (THE BUSIEST MONTHS HISTORICALLY)
The Biden Administration believes they have created new rules that will be in place after MAY 11 title 42 removal to stem the migrant surge issue.
Democratic senators have other ideas.....
opposition to Mr. Biden's post TITLE 42 RULES was led by senators Bob Menendez and Alex Padilla, and also signed by senators Ed Markey, Jeff Merkley, Bernie Sanders, Cory Booker, Elizabeth Warren, Patty Murray, Ron Wyden, Ben Cardin, Ben Ray Lujan and Mazie Hirono.
The scathing rebuke from a dozen Democratic Senators and allies of the White House on most policy matters illustrates the tricky political situation Mr. Biden has found himself in two years into his presidency amid an unprecedented migration crisis along the southern border, where migrants have been arriving in greater numbers and from more countries than any time in U.S. history.
MIGRANT ISSUES ARE NOT GOING AWAY, WE WILL GET ANOTHER SURGE IN THE NEXT FEW MONTHS and it will continue to a problem long term.
This will benefit GEO's financials and help it's current mission to pay down debt and grow it's electronic monitoring division.
For those who have the patience GEO is an excellent bet moving forward over the next 2 years and beyond.
This is my first time posting,
Good luck in all your incarceration related investments,
may GEO become that which i believe it can be......
Pumpin out cashflow and almost debt free
submitted by 30yearsofsaltypain to GeoGroup [link] [comments]
Mr. Biden's recent strategy has taken credit for a drop in the number of migrants attempting to enter the U.S. illegally across the Rio Grande
THIS IS DROP TAKES PLACE EVERY YEAR IN LATE DECEMBER, JANUARY as explained by Mr. Zoley Q4 2022 conference call.
ALSO THE DROP APPEARS MORE PROFOUND BECAUSE THE (ABNORMAL) SURGE IN LATE 2022 WAS QUITE HIGH...MAKING THE DROP LOOK MORE IMPRESSIVE.
The numbers have been ticking up again in March and are now heading towards a surge in April,May, June. (THE BUSIEST MONTHS HISTORICALLY)
The Biden Administration believes they have created new rules that will be in place after MAY 11 title 42 removal to stem the migrant surge issue.
Democratic senators have other ideas.....
opposition to Mr. Biden's post TITLE 42 RULES was led by senators Bob Menendez and Alex Padilla, and also signed by senators Ed Markey, Jeff Merkley, Bernie Sanders, Cory Booker, Elizabeth Warren, Patty Murray, Ron Wyden, Ben Cardin, Ben Ray Lujan and Mazie Hirono.
The scathing rebuke from a dozen Democratic Senators and allies of the White House on most policy matters illustrates the tricky political situation Mr. Biden has found himself in two years into his presidency amid an unprecedented migration crisis along the southern border, where migrants have been arriving in greater numbers and from more countries than any time in U.S. history.
MIGRANT ISSUES ARE NOT GOING AWAY, WE WILL GET ANOTHER SURGE IN THE NEXT FEW MONTHS and it will continue to a problem long term.
This will benefit GEO's financials and help it's current mission to pay down debt and grow it's electronic monitoring division.
For those who have the patience GEO is an excellent bet moving forward over the next 2 years and beyond.
This is my first time posting,
Good luck in all your incarceration related investments,
may GEO become that which i believe it can be......
Pumpin out cashflow and almost debt free
2023.03.30 16:43 packagedmemes ChatGPT not being able to read URL's properly?
 | submitted by packagedmemes to ChatGPT [link] [comments] 1st response to question 2nd response to the same question Both of the responses are wrong, as the topic of the actual link provided is about a gene that's linked to neurodegenerative diseases. In other instances, ChatGPT thought it was reading a link about COVID-19 (2 different times). Here's the link to the actual one provided: https://www.mdpi.com/2073-4409/11/9/1520 Another instance, I asked GPT to summarize the same article, but it had the chat titled: "Weather forecast requested" Why is it doing this? |
2023.03.30 16:32 ItsMe_Hiiii Non-diagnosed, these are some of my symptoms
29 years old and my body feels 120
29/F 5”1’ 140lbs no true medical diagnosis besides a stable hemangioma found in my brain stem during a case of viral meningitis. history of back pain since teens (never taken seriously and told I’m too young and healthy for it to be anything) I’ve since put off doctors because I felt if I wasn’t ever listened to I may as well learn to deal with it. In the last 2ish years it’s gotten worse. I’m now having whole spine pain along with large joints pain. Daily I wake up stiff and sore all over, it takes me 30 minutes to and hour to feel like I can move properly. I clean houses for work and I typically feel okay throughout the day and get a lot accomplished. I’m pretty active, have 3 kids that all play sports, we don’t live a sedentary lifestyle by any means. By evening time I feel like a truck has ran me over multiple times.
Main Symptoms:
Cervical spine pain, headaches from base of right side that shoots up head, when I tuck chin to chest there’s a shooting/pulling sensation in the middle of my back. Tingly into both shoulders and sometimes down into right forearm. When I’m doing any activity that requires arms above chest level my arms feel very tired, kind of ‘buzz’ feeling and feel heavy.
Mid back pain, kind of burning sensation right on spine area. Lower middle back locks up after sitting or resting, when I stand it feels like my back won’t straighten and it takes me a second to slowly get to straight position.
Lower back aches, worse if wearing tighter leggings or jeans..
Hips hurt and feels like they did when I was pregnant, sometimes feel like my hip isn’t moving properly when walking, like it just needs popped or something. Pain radiates down sides of butt and outer thighs.
Knees ache and feel swollen (aren’t visually)
Calves always feel tight or like muscles are pulled, tried massage with no relief.
Ankles feel same as knees
I have trouble sleeping every night because of the pain in each of these areas. I’m constantly tossing and turning trying to find a comfortable position with no success. My legs tingle and feel like I have bugs crawling inside of them at night (I was given medicine for restless legs at one point that didn’t help)
I had a doctors appointment today, she’s doing X-rays from my neck to my hips and blood work (thyroid, ANA, RF, crp and vitamins b12, D) and starting me at physical therapy (due to insurance) before an mri. I guess I’m just here looking for people with similar symptoms and ask what has helped, what was your diagnosis? I just want to feel good again.
submitted by ItsMe_Hiiii to ankylosingspondylitis [link] [comments]
29/F 5”1’ 140lbs no true medical diagnosis besides a stable hemangioma found in my brain stem during a case of viral meningitis. history of back pain since teens (never taken seriously and told I’m too young and healthy for it to be anything) I’ve since put off doctors because I felt if I wasn’t ever listened to I may as well learn to deal with it. In the last 2ish years it’s gotten worse. I’m now having whole spine pain along with large joints pain. Daily I wake up stiff and sore all over, it takes me 30 minutes to and hour to feel like I can move properly. I clean houses for work and I typically feel okay throughout the day and get a lot accomplished. I’m pretty active, have 3 kids that all play sports, we don’t live a sedentary lifestyle by any means. By evening time I feel like a truck has ran me over multiple times.
Main Symptoms:
Cervical spine pain, headaches from base of right side that shoots up head, when I tuck chin to chest there’s a shooting/pulling sensation in the middle of my back. Tingly into both shoulders and sometimes down into right forearm. When I’m doing any activity that requires arms above chest level my arms feel very tired, kind of ‘buzz’ feeling and feel heavy.
Mid back pain, kind of burning sensation right on spine area. Lower middle back locks up after sitting or resting, when I stand it feels like my back won’t straighten and it takes me a second to slowly get to straight position.
Lower back aches, worse if wearing tighter leggings or jeans..
Hips hurt and feels like they did when I was pregnant, sometimes feel like my hip isn’t moving properly when walking, like it just needs popped or something. Pain radiates down sides of butt and outer thighs.
Knees ache and feel swollen (aren’t visually)
Calves always feel tight or like muscles are pulled, tried massage with no relief.
Ankles feel same as knees
I have trouble sleeping every night because of the pain in each of these areas. I’m constantly tossing and turning trying to find a comfortable position with no success. My legs tingle and feel like I have bugs crawling inside of them at night (I was given medicine for restless legs at one point that didn’t help)
I had a doctors appointment today, she’s doing X-rays from my neck to my hips and blood work (thyroid, ANA, RF, crp and vitamins b12, D) and starting me at physical therapy (due to insurance) before an mri. I guess I’m just here looking for people with similar symptoms and ask what has helped, what was your diagnosis? I just want to feel good again.